Fulminant Epstein-Barr virus esophagitis in an immunocompetent patient.

pital with a 3-week history of fever, nausea, and dysphagia. He had undergone bilateral femoral amputation 5 years ago following an accident. Besides hypertension he had no other pathology. He lived with his family and was a smoker but did not take any drugs or alcohol. On examination, his skin was pale and there was slight epigastric tenderness. Initial laboratory tests revealed normocytic anemia. Abdominal ultrasound showed hepatosplenomegaly. The patient was admitted and upper endoscopy carried out, which revealed severe esophagitis with denuded ulcers (●" Fig. 1). Histological examination of the biopsy samples was noninformative, showing lymphocytic esophagitis with CD3 positive T-cells in the mucosa (●" Fig. 2). Mononuclear cells were observed in the peripheral blood, but there was no evidence of a malignant hematological disorder. Blood, urinary, and esophageal cultures were negative for bacteria. The patient was also negative for human immunodeficiency virus (HIV) antibody and antigen, HBsAg, and HCV antibody. Serological examinations suggested a previous herpes simplex virus (HSV) 1,2 and Epstein–Barr virus (EBV) infection, but realtime polymerase chain reaction (PCR) of a peripheral blood sample proved negative for these viruses. The patient was given intravenous proton-pump inhibitor therapy along with oral sucralfate suspension, but there was no clinical improvement after 1 week. Instead, he had an episode of hematemesis, and a repeat endoscopy showed increased ulceration in the esophagus (●" Fig. 3). Esophageal biopsies were taken for PCR, which was negative for cytomegalovirus and HSV, but highly positive for EBV (8040 copies/mL). Aciclovir therapy was initiated (5 × 800mg) and continued for 2 weeks. After 1 month of this treatment, the esophagitis resolved completely, and was confirmed by endoscopy (●" Fig. 4). EBV esophagitis is a rare pathological presentation that may occur in immunocompetent patients [1,2]. Our case highlights the importance of undertaking PCR on tisFulminant Epstein–Barr virus esophagitis in an immunocompetent patient